Reduction of venous pressure during the resection of liver metastases
compromises enteric blood flow: IGFBP-1 as a novel biomarker of intestinal barrier injury

HV Barbeiro, Machado MA, HP Souza, FP Silva, MC Machado

Clinics. 2017;72(10):645-648

https:// 10.6061/clinics/2017(10)10



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OBJECTIVES: Disruption of the intestinal barrier and bacterial translocation commonly occur when intestinal
blood flow is compromised. The aim of this study was to determine whether liver resection induces intestinal
METHODS: We investigated intestinal fatty-acid binding protein and insulin-like growth factor binding protein
levels in the plasma of patients who underwent liver resection.
RESULTS: We show that liver resection is associated with significant intestinal barrier injury, even if the Pringle
maneuver is not performed.
CONCLUSION: We propose the use of insulin-like growth factor binding protein-1 as a novel biomarker of
intestinal damage in such situations.