Artigos Nacionais - Resumo

Surgical Treatment of Colorectal Cancer Hepatic Metastases. Experience of A.C. Camargo Cancer Hospital - São Paulo (em inglês).
Autores: Herman P, Machado MA, Diniz AL, Coimbra FJ, Sallum RA, Montagnini AL.

Applied Cancer Research 2006;26(3):88-93.



Introduction: Colorectal cancer is the fourth leading cause of malignancy in Brazil, as well as in the US. Hepatic metastasis, occur in up to 50% of patients during the course of the disease. To date, surgical resection is the standard treatment, and is associated with the best survival outcome. Identifying prognostic factors is important for better patient selection. Patients and Methods: Data of 70 patients submitted to hepatic resection of colorectal metastasis with curative intent between January 1999 and June 2005 were reviewed Clinical data and surgical pathology features of all patients were analyzed. Results: 76 procedures were performed in 70 patients, Global estimated survival was 51 % in 5 years. Prognostic significantly variables were number of metastasis, bilaterality and preoperative CEA. Postoperative death occurred only in one patient, due to infection and sepsis. Conclusion: Surgical resection is the best treatment for colorectal hepatic metastasis, though prognostic factors imply worst outcome, survival is better than non surgical treatment. In this series we identified objective prognostic factors which might help the physician to select the best moment of resection and add systemic treatments.